{"id":21,"date":"2024-06-10T13:50:32","date_gmt":"2024-06-10T13:50:32","guid":{"rendered":"https:\/\/freichel-lab.org\/?page_id=21"},"modified":"2025-05-07T12:13:18","modified_gmt":"2025-05-07T12:13:18","slug":"home-2","status":"publish","type":"page","link":"https:\/\/freichel-lab.org\/","title":{"rendered":"Home"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"21\" class=\"elementor elementor-21\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a5c3705 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-id=\"a5c3705\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;video&quot;,&quot;background_video_link&quot;:&quot;https:\\\/\\\/freichel-lab.org\\\/wp-content\\\/uploads\\\/2024\\\/11\\\/Unbenanntes%20Video%20%E2%80%93%20Mit%20Clipchamp%20erstellt.mp4&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-background-video-container elementor-hidden-mobile\">\n\t\t\t\t\t\t\t<video class=\"elementor-background-video-hosted\" role=\"presentation\" autoplay muted playsinline loop><\/video>\n\t\t\t\t\t<\/div><div class=\"elementor-element elementor-element-832687f e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"832687f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-f1a8b68 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"f1a8b68\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4aca3e7 elementor-widget__width-initial exad-sticky-section-no exad-glass-effect-no elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"4aca3e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">INNOVATING CARDIOVASCULAR HEALTH THROUGH ION CHANNEL RESEARCH<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-93a9441 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"93a9441\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e53d19a elementor-align-right elementor-widget__width-initial exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-elementskit-button\" data-id=\"e53d19a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"elementskit-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >\t\t<div class=\"ekit-btn-wraper\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/freichel-lab.org\/?page_id=211\" class=\"elementskit-btn  whitespace--normal\" id=\"\">\n\t\t\t\t\t<i class=\"jki jki-contact-form-light\"><\/i>Contact Us\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n        <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-273efed elementor-align-left elementor-widget__width-initial exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-elementskit-button\" data-id=\"273efed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"elementskit-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"ekit-wid-con\" >\t\t<div class=\"ekit-btn-wraper\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/freichel-lab.org\/?page_id=14\" class=\"elementskit-btn  whitespace--normal\" id=\"\">\n\t\t\t\t\t<i class=\"jki jki-team1-light\"><\/i>Our Team\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n        <\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e0e65c3 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-id=\"e0e65c3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e7674a9 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"e7674a9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8ac871d elementor-view-default exad-sticky-section-no exad-glass-effect-no elementor-invisible elementor-widget elementor-widget-icon\" data-id=\"8ac871d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<i aria-hidden=\"true\" class=\"jki jki-microscope-light\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-319c7bb elementor-widget__width-initial exad-sticky-section-no exad-glass-effect-no elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"319c7bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Welcome<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b9304e8 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"b9304e8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7019a8a elementor-widget__width-initial exad-sticky-section-no exad-glass-effect-no elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"7019a8a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-size: 22px; color: #000000; font-family: 'Manrope', Helvetica, Arial, Lucida, sans-serif;\">At the forefront of cardiovascular health, we lead groundbreaking research on ion channel dynamics and their impact on cellular processes. Our work spans molecular mechanisms, translational applications, and therapeutic advancements aimed at improving global health outcomes. With a commitment to excellence, we collaborate across disciplines to address some of the most pressing challenges in biomedicine today.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6d6a3be e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-id=\"6d6a3be\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-11c4d7f e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"11c4d7f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f71ab39 exad-sticky-section-no exad-glass-effect-no elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"f71ab39\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Key Research Highlights<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-13cd1fb exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-spacer\" data-id=\"13cd1fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ee1e5c4 elementor-widget__width-initial exad-sticky-section-no exad-glass-effect-no elementor-invisible elementor-widget elementor-widget-eael-feature-list\" data-id=\"ee1e5c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"eael-feature-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"-icon-position-left -tablet-icon-position-left -mobile-icon-position-left\">\n\t\t\t<ul id=\"eael-feature-list-ee1e5c4\" class=\"eael-feature-list-items circle stacked  eael-feature-list-vertical\" data-layout-tablet=\"vertical\" data-layout-mobile=\"vertical\">\n\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-97f5bb9\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-0\">\n\n\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-microscope\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M160 320h12v16c0 8.84 7.16 16 16 16h40c8.84 0 16-7.16 16-16v-16h12c17.67 0 32-14.33 32-32V64c0-17.67-14.33-32-32-32V16c0-8.84-7.16-16-16-16h-64c-8.84 0-16 7.16-16 16v16c-17.67 0-32 14.33-32 32v224c0 17.67 14.33 32 32 32zm304 128h-1.29C493.24 413.99 512 369.2 512 320c0-105.88-86.12-192-192-192v64c70.58 0 128 57.42 128 128s-57.42 128-128 128H48c-26.51 0-48 21.49-48 48 0 8.84 7.16 16 16 16h480c8.84 0 16-7.16 16-16 0-26.51-21.49-48-48-48zm-360-32h208c4.42 0 8-3.58 8-8v-16c0-4.42-3.58-8-8-8H104c-4.42 0-8 3.58-8 8v16c0 4.42 3.58 8 8 8z\"><\/path><\/svg>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Functional and Molecular Specificity of OCaR-Dependent Calcium Release<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\">- Investigating the role of OCaR1 and OCaR2 in NAADP-mediated Ca\u00b2\u207a signaling.\n- Utilizing affinity, proximity, and organellar proteomics to understand OCaR-driven Ca\u00b2\u207a signaling in various cell types.<\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-ce07bb4\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-1\">\n\n\t\t<i aria-hidden=\"true\" class=\"jki jki-dot-circle-solid\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Molecular Circuits Leading to Ventricular Arrhythmias<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\">- Identifying OCaR2 as a regulator of lysosomal two-pore channels.\n<br>\n- Combining Ca\u00b2\u207a imaging, ECG telemetry, and computational methods to elucidate pathways causing catecholaminergic arrhythmias.<\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-0f3720a\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-2\">\n\n\t\t<i aria-hidden=\"true\" class=\"remixicon ri-heart-pulse-fill\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Integrated Graduate School for CardioScience<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\">- Promoting young Cardioscientists through a comprehensive training program.\n<br>\n- Enhancing cardiovascular research by providing state-of-the-art experimental approaches and mentoring.\n<\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t                <li class=\"eael-feature-list-item elementor-repeater-item-cc662c1\">\n                    \n\t\t\t\t\t\t<div class=\"eael-feature-list-icon-box\">\n\t\t\t\t\t\t\t<div class=\"eael-feature-list-icon-inner\">\n\n\t\t\t\t\t\t\t\t<span class=\"eael-feature-list-icon fl-icon-3\">\n\n\t\t<i aria-hidden=\"true\" class=\"remixicon ri-signal-tower-fill\"><\/i>\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"eael-feature-list-content-box\">\n                            <p class=\"eael-feature-list-title\">Adenine-Nucleotide Signal Transduction in Mast Cell Activation<\/p>\t\t\t\t\t\t<p class=\"eael-feature-list-content\">- Exploring the role of adenine nucleotides in regulating Ca\u00b2\u207a homeostasis in mast cells.\n<br>\n- Applying electrophysiology and imaging techniques to investigate the interaction of Orai and TPC channels in inflammation.<\/p>\n\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t<\/ul>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a71cf83 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-id=\"a71cf83\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-fa5ee6c e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"fa5ee6c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4d36729 elementor-widget__width-initial exad-sticky-section-no exad-glass-effect-no elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"4d36729\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Platform for CRISPR\/Cas9 technology and AAV8 atherosclerosis model<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e95378e exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-spacer\" data-id=\"e95378e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4c5210a e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"4c5210a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-567b466 exad-sticky-section-no exad-glass-effect-no elementor-invisible elementor-widget elementor-widget-eael-sticky-video\" data-id=\"567b466\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"eael-sticky-video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"eael-sticky-video-wrapper eaelsv-overlay-visibility-\"><div class=\"eael-sticky-video-player2\" data-sticky=\"\" data-position=\"\" data-sheight=\"169\" data-swidth=\"300\" data-scroll_height=\"\" data-autoplay=\"no\" data-overlay=\"no\"><video class=\"eaelsv-player\" id=\"eaelsv-player-567b466\" playsinline controls data-plyr-config=\"{&quot;autoplay&quot;:0, &quot;muted&quot;:0, &quot;loop&quot;: {&quot;active&quot;: false}}\">\n\t\t\t<source src=\"https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/VA_210924M28-Final.mov#t=,\" type=\"video\/mp4\" \/>\n\t\t<\/video>\n\t\t\t\t<span class=\"eaelsv-sticky-player-close\"><i class=\"fas fa-times-circle\"><\/i><\/span>\n\t\t\t<\/div>\n\t\t<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d6a0be8 wpr-button-icon-style-inline wpr-button-icon-position-right exad-sticky-section-no exad-glass-effect-no elementor-invisible elementor-widget elementor-widget-wpr-button\" data-id=\"d6a0be8\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"wpr-button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\n\t\t\t\n\t\t\n\t\t<div class=\"wpr-button-wrap elementor-clearfix\">\n\t\t<a class=\"wpr-button wpr-button-effect wpr-button-none\" data-text=\"\" href=\"https:\/\/freichel-lab.org\/?page_id=3626\">\n\t\t\t\n\t\t\t<span class=\"wpr-button-content\">\n\t\t\t\t\t\t\t\t\t<span class=\"wpr-button-text\">More<\/span>\n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<span class=\"wpr-button-icon\"><svg class=\"e-font-icon-svg e-fas-angle-right\" viewBox=\"0 0 256 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M224.3 273l-136 136c-9.4 9.4-24.6 9.4-33.9 0l-22.6-22.6c-9.4-9.4-9.4-24.6 0-33.9l96.4-96.4-96.4-96.4c-9.4-9.4-9.4-24.6 0-33.9L54.3 103c9.4-9.4 24.6-9.4 33.9 0l136 136c9.5 9.4 9.5 24.6.1 34z\"><\/path><\/svg><\/span>\n\t\t\t\t\t\t\t<\/span>\n\t\t<\/a>\n\n\t\t\t\t<\/div>\n\t\n\t\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-17434f4 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-id=\"17434f4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-e0c5827 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"e0c5827\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-583ec49 exad-sticky-section-no exad-glass-effect-no elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"583ec49\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Selected publications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2dfbf0b elementor-widget__width-inherit exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-spacer\" data-id=\"2dfbf0b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3a47b2a e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no elementor-invisible e-con e-child\" data-id=\"3a47b2a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;zoomIn&quot;}\">\n\t\t<a class=\"eael-wrapper-link-e17f010 --eael-wrapper-link-tag\" href=\"https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g1.png\"><\/a><div data-eael-wrapper-link=\"eael-wrapper-link-e17f010\" class=\"elementor-element elementor-element-e17f010 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"e17f010\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c7fc301 elementor-widget__width-initial exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"c7fc301\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"528\" src=\"https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g1-1024x844.png\" class=\"attachment-large size-large wp-image-3896\" alt=\"\" srcset=\"https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g1-1024x844.png 1024w, https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g1-300x247.png 300w, https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g1-768x633.png 768w, https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g1-1536x1266.png 1536w, https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g1-2048x1687.png 2048w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d919165 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"d919165\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-282a1db elementor-widget__width-initial exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"282a1db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia.<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c89a387 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"c89a387\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span style=\"color: #000000; font-size: 12px;\">Br\u00f6ker-Lai J, Rego Terol J, Richter C, Mathar I, Wirth A, Kopf S, Moreno-P\u00e9rez A, B\u00fcttner M, Tan LL, Makke M, Poschet G, Hermann J, Tsvilovskyy V, Haberkorn U, Wartenberg P, Susperreguy S, Berlin M, Ottenheijm R, Philippaert K, Wu M, Wiedemann T, Herzig S, Belkacemi A, Levinson RT, Agarwal N, Camacho Londo\u00f1o JE, Klebl B, Dinkel K, Zufall F, Nussbaumer P, Boehm U, Hell R, Nawroth P, Birnbaumer L, Leinders-Zufall T, Kuner R, Zorn M, Bruns D, Schwarz Y,\u00a0<strong>Freichel M.\n<\/strong><\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8ec62c1 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no elementor-invisible e-con e-child\" data-id=\"8ec62c1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;zoomIn&quot;}\">\n\t\t<a class=\"eael-wrapper-link-5e39855 --eael-wrapper-link-tag\" href=\"https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g1.png\"><\/a><div data-eael-wrapper-link=\"eael-wrapper-link-5e39855\" class=\"elementor-element elementor-element-5e39855 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"5e39855\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5f733de elementor-widget__width-initial exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"5f733de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"496\" src=\"https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g3-1024x793.png\" class=\"attachment-large size-large wp-image-3987\" alt=\"\" srcset=\"https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g3-1024x793.png 1024w, https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g3-300x232.png 300w, https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g3-768x595.png 768w, https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g3-1536x1190.png 1536w, https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g3-2048x1586.png 2048w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-66ef162 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"66ef162\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d04f2b4 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"d04f2b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">The many facets of TMEM63\/OCaR proteins as mechanosensitive channels in lysosomes, NAADP signaling and beyond.<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a51b1fa exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"a51b1fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span style=\"color: #000000; font-size: 12px;\"><strong>Freichel M<\/strong>, Tsvilovskyy V, Philippaert K, Schulte U, Ottenheijm R. <\/span><span style=\"color: #000000; font-size: 12px;\">\nCell Calcium. 2024 Nov;123:102942. doi: 10.1016\/j.ceca.2024.102942. Epub 2024 Aug 4.PMID: 39121527<\/span>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bbb0258 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no elementor-invisible e-con e-child\" data-id=\"bbb0258\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;zoomIn&quot;}\">\n\t\t<a class=\"eael-wrapper-link-1a1fed3 --eael-wrapper-link-tag\" href=\"https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g1.png\"><\/a><div data-eael-wrapper-link=\"eael-wrapper-link-1a1fed3\" class=\"elementor-element elementor-element-1a1fed3 e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"1a1fed3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d79be9e elementor-widget__width-inherit exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"d79be9e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"640\" height=\"528\" src=\"https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g-3-1-1024x844.png\" class=\"attachment-large size-large wp-image-4035\" alt=\"\" srcset=\"https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g-3-1-1024x844.png 1024w, https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g-3-1-300x247.png 300w, https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g-3-1-768x633.png 768w, https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g-3-1-1536x1266.png 1536w, https:\/\/freichel-lab.org\/wp-content\/uploads\/2024\/11\/g-3-1-2048x1687.png 2048w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-55716cd e-con-full e-flex wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-child\" data-id=\"55716cd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d401262 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"d401262\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage.<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9067b36 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"9067b36\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<span style=\"color: #000000; font-size: 12px;\">Tsvilovskyy V, Ottenheijm R, Kriebs U, Sch\u00fctz A, Diakopoulos KN, Jha A, Bildl W, Wirth A, B\u00f6ck J, Ja\u015blan D, Ferro I, Taberner FJ, Kalinina O, Hildebrand S, Wissenbach U, Weissgerber P, Vogt D, Eberhagen C, Mannebach S, Berlin M, Kuryshev V, Schumacher D, Philippaert K, Camacho-Londo\u00f1o JE, Mathar I, Dieterich C, Klugbauer N, Biel M, Wahl-Schott C, Lipp P, Flockerzi V, Zischka H, Alg\u00fcl H, Lechner SG, Lesina M, Grimm C, Fakler B, Schulte U, Muallem S,\u00a0<strong>Freichel M.\n<\/strong><\/span><span style=\"color: #000000; font-size: 12px;\">J Clin Invest. 2024 Apr 1;134(7):e169428. doi: 10.1172\/JCI169428.PMID:\u00a038557489\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>INNOVATING CARDIOVASCULAR HEALTH THROUGH ION CHANNEL RESEARCH Contact Us Our Team Welcome At the forefront of cardiovascular health, we lead groundbreaking research on ion channel dynamics and their impact on cellular processes. Our work spans molecular mechanisms, translational applications, and therapeutic advancements aimed at improving global health outcomes. With a commitment to excellence, we collaborate across disciplines to address some of the most pressing challenges in biomedicine today. Key Research Highlights Functional and Molecular Specificity of OCaR-Dependent Calcium Release &#8211; Investigating the role of OCaR1 and OCaR2 in NAADP-mediated Ca\u00b2\u207a signaling. &#8211; Utilizing affinity, proximity, and organellar proteomics to understand OCaR-driven Ca\u00b2\u207a signaling in various cell types. Molecular Circuits Leading to Ventricular Arrhythmias &#8211; Identifying OCaR2 as a regulator of lysosomal two-pore channels. &#8211; Combining Ca\u00b2\u207a imaging, ECG telemetry, and computational methods to elucidate pathways causing catecholaminergic arrhythmias. Integrated Graduate School for CardioScience &#8211; Promoting young Cardioscientists through a comprehensive training program. &#8211; Enhancing cardiovascular research by providing state-of-the-art experimental approaches and mentoring. Adenine-Nucleotide Signal Transduction in Mast Cell Activation &#8211; Exploring the role of adenine nucleotides in regulating Ca\u00b2\u207a homeostasis in mast cells. &#8211; Applying electrophysiology and imaging techniques to investigate the interaction of Orai and TPC channels in inflammation. Platform for CRISPR\/Cas9 technology and AAV8 atherosclerosis model More Selected publications TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia. Br\u00f6ker-Lai J, Rego Terol J, Richter C, Mathar I, Wirth A, Kopf S, Moreno-P\u00e9rez A, B\u00fcttner M, Tan LL, Makke M, Poschet G, Hermann J, Tsvilovskyy V, Haberkorn U, Wartenberg P, Susperreguy S, Berlin M, Ottenheijm R, Philippaert K, Wu M, Wiedemann T, Herzig S, Belkacemi A, Levinson RT, Agarwal N, Camacho Londo\u00f1o JE, Klebl B, Dinkel K, Zufall F, Nussbaumer P, Boehm U, Hell R, Nawroth P, Birnbaumer L, Leinders-Zufall T, Kuner R, Zorn M, Bruns D, Schwarz Y,\u00a0Freichel M. The many facets of TMEM63\/OCaR proteins as mechanosensitive channels in lysosomes, NAADP signaling and beyond. Freichel M, Tsvilovskyy V, Philippaert K, Schulte U, Ottenheijm R. Cell Calcium. 2024 Nov;123:102942. doi: 10.1016\/j.ceca.2024.102942. Epub 2024 Aug 4.PMID: 39121527 OCaR1 endows exocytic vesicles with autoregulatory competence by preventing uncontrolled Ca2+ release, exocytosis, and pancreatic tissue damage. Tsvilovskyy V, Ottenheijm R, Kriebs U, Sch\u00fctz A, Diakopoulos KN, Jha A, Bildl W, Wirth A, B\u00f6ck J, Ja\u015blan D, Ferro I, Taberner FJ, Kalinina O, Hildebrand S, Wissenbach U, Weissgerber P, Vogt D, Eberhagen C, Mannebach S, Berlin M, Kuryshev V, Schumacher D, Philippaert K, Camacho-Londo\u00f1o JE, Mathar I, Dieterich C, Klugbauer N, Biel M, Wahl-Schott C, Lipp P, Flockerzi V, Zischka H, Alg\u00fcl H, Lechner SG, Lesina M, Grimm C, Fakler B, Schulte U, Muallem S,\u00a0Freichel M. J Clin Invest. 2024 Apr 1;134(7):e169428. doi: 10.1172\/JCI169428.PMID:\u00a038557489<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-21","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.10 - aioseo.com -->\n\t<meta name=\"description\" content=\"INNOVATING CARDIOVASCULAR HEALTH THROUGH ION CHANNEL RESEARCH Contact Us Our Team Welcome At the forefront of cardiovascular health, we lead groundbreaking research on ion channel dynamics and their impact on cellular processes. Our work spans molecular mechanisms, translational applications, and therapeutic advancements aimed at improving global health outcomes. 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