{"id":3500,"date":"2024-11-05T14:22:08","date_gmt":"2024-11-05T14:22:08","guid":{"rendered":"https:\/\/freichel-lab.org\/?page_id=3500"},"modified":"2024-11-05T14:22:31","modified_gmt":"2024-11-05T14:22:31","slug":"crc1550","status":"publish","type":"page","link":"https:\/\/freichel-lab.org\/?page_id=3500","title":{"rendered":"CRC1550"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3500\" class=\"elementor elementor-3500\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f2bf43 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"6f2bf43\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fdb364b exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-sp-wp-tabs-shortcode-ew\" data-id=\"fdb364b\" data-element_type=\"widget\" data-widget_type=\"sp-wp-tabs-shortcode-ew.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style id=\"sp_tab_dynamic_style3499\">#sp-tabpro-wrapper_3499.sp-tab__lay-default .sp-tab__tab-content {width: 100%;}#sp-tabpro-wrapper_3499 .animated {-webkit-animation-duration: 500ms;animation-duration: 500ms;}#sp-wp-tabs-wrapper_3499 .sp-tab__nav {justify-content: start;}#sp-wp-tabs-wrapper_3499.sp-tab__lay-default.sp-tab__horizontal-bottom {display: flex;flex-direction: column-reverse;}#sp-wp-tabs-wrapper_3499.sp-tab__lay-default.sp-tab__horizontal-bottom > ul {border-top: 1px solid #cccccc;border-bottom: 0;margin-top: 0;}#sp-wp-tabs-wrapper_3499.sp-tab__lay-default.sp-tab__horizontal-bottom > ul > li .sp-tab__nav-link.sp-tab__active {border-color: transparent #cccccc#cccccc;margin-top: -1px;}#sp-wp-tabs-wrapper_3499.sp-tab__lay-default.sp-tab__horizontal-bottom > ul > li .sp-tab__nav-link,#sp-wp-tabs-wrapper_3499.sp-tab__lay-default.sp-tab__horizontal-bottom > ul > li a,#sp-wp-tabs-wrapper_3499.sp-tab__lay-default.sp-tab__horizontal-bottom > ul > .sp-tab__nav-item {border-top: 0;border-top-left-radius: 0;border-top-right-radius: 0;border-bottom-left-radius: 2px;border-bottom-right-radius: 2px;}#sp-wp-tabs-wrapper_3499.sp-tab__lay-default.sp-tab__horizontal-bottom > ul {border-bottom: none;}#sp-wp-tabs-wrapper_3499.sp-tab__lay-default.sp-tab__horizontal-bottom .sp-tab__tab-content .sp-tab__tab-pane {border-top: 1px solid #cccccc;border-bottom: 0;}#sp-wp-tabs-wrapper_3499.sp-tab__lay-default .sp-tab__tab-content .sp-tab-content > ul,#sp-wp-tabs-wrapper_3499.sp-tab__lay-default .sp-tab__tab-content .sp-tab-content > ol {border-bottom: none;}#sp-wp-tabs-wrapper_3499 > .sp-tab__nav-tabs .sp-tab__nav-link.sp-tab__active .sp-tab__tab_title,#sp-wp-tabs-wrapper_3499.sp-tab__lay-default .sp-tab__nav-link > .sp-tab__card-header {color: #ffffff;}#sp-wp-tabs-wrapper_3499 > .sp-tab__nav-tabs > .sp-tab__nav-item.show .sp-tab__nav-link,#sp-wp-tabs-wrapper_3499 > .sp-tab__nav-tabs > .sp-tab__nav-item .sp-tab__nav-link.sp-tab__active,#sp-wp-tabs-wrapper_3499.sp-tab__lay-default .sp-tab__nav-link > .sp-tab__card-header {background-color: #0844b0;}#sp-wp-tabs-wrapper_3499 .sp-tab__nav-tabs .sp-tab__nav-item.show .sp-tab__nav-link,#sp-wp-tabs-wrapper_3499.sp-tab__lay-default ul li .sp-tab__nav-link.sp-tab__active {border-color: #cccccc#cccccc transparent;}#sp-wp-tabs-wrapper_3499.sp-tab__lay-default > ul > li > .sp-tab__nav-link,#sp-wp-tabs-wrapper_3499.sp-tab__lay-default > ul > li > a {cursor: pointer;border-color: #cccccc;padding-top: 15px;padding-right: 15px;padding-bottom: 15px;padding-left: 15px;}#sp-wp-tabs-wrapper_3499 > .sp-tab__nav-tabs .sp-tab__nav-link {border: 1px solid #cccccc;height: 100%;}#sp-wp-tabs-wrapper_3499.sp-tab__lay-default > ul > li .sp-tab__nav-link,#sp-wp-tabs-wrapper_3499.sp-tab__lay-default > ul > li a,#sp-wp-tabs-wrapper_3499.sp-tab__lay-default > ul > .sp-tab__nav-item {border-top-left-radius: 2px;border-top-right-radius: 2px;}#sp-wp-tabs-wrapper_3499 .sp-tab__nav-tabs .sp-tab__nav-item {margin-bottom: -1px; 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We combine Ca2+ imaging, ECG telemetry, transcriptome and metabolome approaches with computational methods to elucidate pathways and patterns of gene regulation. By comparative analysis of circuits in arrhythmogenic cardiomyopathy models, we aim to determine common molecular circuits in the pathogenesis of catecholamine driven ventricular arrhythmias.<\/span><\/p>\n<p><span style=\"color: #000000\"><strong><span class=\"name\">Subproject of: <\/span><\/strong><span class=\"value\"><a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/projekt\/464424253\">SFB 1550:\u00a0 Molecular Circuits of Heart Disease<\/a><br \/>\n<\/span><strong><span class=\"name\">Project Heads: <\/span><\/strong><span class=\"value\"><a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/person\/1773715\">Professor Dr. Marc Freichel<\/a>;\u00a0<a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/person\/508147807\">Rebecca Levinson, Ph.D.<\/a><br \/>\n<\/span><em>Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 464424253<\/em><\/span><\/p>\n<p><span style=\"color: #000000\"><strong>Website:<\/strong> <a style=\"color: #000000\" href=\"https:\/\/www.crc1550.com\/project-b09\">https:\/\/www.crc1550.com\/project-b09<\/a><\/span><\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<div id=\"tab-34992\" class=\"sp-tab__tab-pane \" role=\"tabpanel\">\n\t\t\t\t\t<div class=\"sp-tab-content animated fadeIn\"><h3 class=\"facelift\"><span style=\"color: #000000\">Integrated Research Training Group for CardioScience.<\/span><\/h3>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000\">It is the central aim of the Integrated Research Training Group (IRTG) to promote young promising Cardioscientists. An ambitious study program dedicated to state of the art experimental approaches combining CRC 1550-specific training, mentoring and supervision will provide PhD and MD research students and post graduate young academics with the knowledge required for successful and efficient analysis of potential molecular circuits of heart disease. A completion of the program will not only increase competitiveness of our young academics in science and on the labor market but will also enhance the advancement of cardiovascular research by strengthening the leadership of future scientists\u2019 generations in Cardioscience.<\/span><\/p>\n<p><span style=\"color: #000000\"><strong><span class=\"name\">Subproject of: <\/span><\/strong><span class=\"value\"><a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/projekt\/464424253\">SFB 1550:\u00a0 Molecular Circuits of Heart Disease<\/a><\/span><\/span><br \/>\n<span style=\"color: #000000\"><span class=\"name\"><strong>Project Head:<\/strong> <\/span><span class=\"value\"><a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/person\/1773715\">Professor Dr. Marc Freichel<\/a><br \/>\n<\/span><em>Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 464424253<\/em><\/span><\/p>\n<p><span style=\"color: #000000\"><strong>Website:<\/strong> <a style=\"color: #000000\" href=\"https:\/\/www.crc1550.com\/project-s01\">https:\/\/www.crc1550.com\/project-s01<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>CRC1550 B09 S01 Unraveling molecular circuits leading to catecholamine-driven ventricular arrhythmias We identified OCaR2 as a regulator of lysosomal two-pore channels, and its deletion resulted in Ca2+ oscillations in cardiomyocytes causing fatal catecholaminergic arrhythmias. We combine Ca2+ imaging, ECG telemetry, transcriptome and metabolome approaches with computational methods to elucidate pathways and patterns of gene regulation. By comparative analysis of circuits in arrhythmogenic cardiomyopathy models, we aim to determine common molecular circuits in the pathogenesis of catecholamine driven ventricular arrhythmias. Subproject of: SFB 1550:\u00a0 Molecular Circuits of Heart Disease Project Heads: Professor Dr. Marc Freichel;\u00a0Rebecca Levinson, Ph.D. Deutsche Forschungsgemeinschaft (DFG) &#8211; Projektnummer 464424253 Website: https:\/\/www.crc1550.com\/project-b09 Integrated Research Training Group for CardioScience It is the central aim of the Integrated Research Training Group (IRTG) to promote young promising Cardioscientists. An ambitious study program dedicated to state of the art experimental approaches combining CRC 1550-specific training, mentoring and supervision will provide PhD and MD research students and post graduate young academics with the knowledge required for successful and efficient analysis of potential molecular circuits of heart disease. A completion of the program will not only increase competitiveness of our young academics in science and on the labor market but will also enhance the advancement of cardiovascular research by strengthening the leadership of future scientists\u2019 generations in Cardioscience. Subproject of: SFB 1550:\u00a0 Molecular Circuits of Heart Disease Project Head: Professor Dr. Marc Freichel Deutsche Forschungsgemeinschaft (DFG) &#8211; Projektnummer 464424253 Website: https:\/\/www.crc1550.com\/project-s01 &nbsp;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-pagefull.php","meta":{"footnotes":""},"class_list":["post-3500","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages\/3500","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3500"}],"version-history":[{"count":5,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages\/3500\/revisions"}],"predecessor-version":[{"id":4368,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages\/3500\/revisions\/4368"}],"wp:attachment":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3500"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}