{"id":3531,"date":"2024-11-07T11:57:43","date_gmt":"2024-11-07T11:57:43","guid":{"rendered":"https:\/\/freichel-lab.org\/?page_id=3531"},"modified":"2024-11-07T11:58:19","modified_gmt":"2024-11-07T11:58:19","slug":"sfb1328","status":"publish","type":"page","link":"https:\/\/freichel-lab.org\/?page_id=3531","title":{"rendered":"SFB1328"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3531\" class=\"elementor elementor-3531\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5dc2aa4 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no wpr-column-slider-no wpr-equal-height-no e-con e-parent\" data-id=\"5dc2aa4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3fc9a5f exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-sp-wp-tabs-shortcode-ew\" data-id=\"3fc9a5f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"sp-wp-tabs-shortcode-ew.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style id=\"sp_tab_dynamic_style3530\">#sp-tabpro-wrapper_3530.sp-tab__lay-default .sp-tab__tab-content {width: 100%;}#sp-tabpro-wrapper_3530 .animated {-webkit-animation-duration: 500ms;animation-duration: 500ms;}#sp-wp-tabs-wrapper_3530 .sp-tab__nav { justify-content: flex-start; 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Ca2+ entry and cytosolic Ca2+ rise is essential for inflammatory mediator release from mast cells. Adenine nucleotides (AN) such as adenosine, ATP or NAADP regulate mast cell Ca2+ homeostasis and function via endolysosomal two-pore channels (TPCs) and plasmalemmal channels. We will apply (endolysosomal) patch-clamp electrophysiology, imaging techniques, cell biological assays and mouse models to investigate the role of Orai and TPC channels and novel interaction partners of these for mast cell-mediated inflammation.<\/span><\/p>\n<p><span style=\"color: #000000\"><strong><span class=\"name\">Subproject of: <\/span><\/strong><\/span><span class=\"value\"><span style=\"color: #000000\"><a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/projekt\/335447717\">SFB 1328:\u00a0 Adenine Nucleotides in Immunity and Inflammation<\/a><\/span><br \/>\n<span style=\"color: #000000\"><strong><span class=\"name\">Project Heads: <\/span><\/strong><a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/person\/1773715\">Professor Dr. Marc Freichel<\/a>;\u00a0<a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/person\/233867230\">Professor Dr. Christian Michael Grimm<\/a><\/span><br \/>\n<\/span><\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>SFB 1328 A21 Adenine nucleotide signaling in Ca2+-dependent mast cell activation: role of endolysosomal and plasmalemmal channels Mast cells are immune cells that essentially contribute to various inflammatory processes. Ca2+ entry and cytosolic Ca2+ rise is essential for inflammatory mediator release from mast cells. Adenine nucleotides (AN) such as adenosine, ATP or NAADP regulate mast cell Ca2+ homeostasis and function via endolysosomal two-pore channels (TPCs) and plasmalemmal channels. We will apply (endolysosomal) patch-clamp electrophysiology, imaging techniques, cell biological assays and mouse models to investigate the role of Orai and TPC channels and novel interaction partners of these for mast cell-mediated inflammation. Subproject of: SFB 1328:\u00a0 Adenine Nucleotides in Immunity and Inflammation Project Heads: Professor Dr. Marc Freichel;\u00a0Professor Dr. Christian Michael Grimm<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-pagefull.php","meta":{"footnotes":""},"class_list":["post-3531","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"SFB 1328 A21 Adenine nucleotide signaling in Ca2+-dependent mast cell activation: role of endolysosomal and plasmalemmal channels. Mast cells are immune cells that essentially contribute to various inflammatory processes. Ca2+ entry and cytosolic Ca2+ rise is essential for inflammatory mediator release from mast cells. Adenine nucleotides (AN) such as adenosine, ATP or NAADP regulate\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/freichel-lab.org\/?page_id=3531\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 5.0.0.1\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_US\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Freichel Lab - UNLOCKING CALCIUM&#039;S SECRETS BY PIONEERING ADVANCES IN CARDIOVASCULAR AND CELLULAR RESEARCH\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"SFB1328 - Freichel Lab\" \/>\n\t\t<meta property=\"og:description\" content=\"SFB 1328 A21 Adenine nucleotide signaling in Ca2+-dependent mast cell activation: role of endolysosomal and plasmalemmal channels. Mast cells are immune cells that essentially contribute to various inflammatory processes. 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