{"id":3531,"date":"2024-11-07T11:57:43","date_gmt":"2024-11-07T11:57:43","guid":{"rendered":"https:\/\/freichel-lab.org\/?page_id=3531"},"modified":"2024-11-07T11:58:19","modified_gmt":"2024-11-07T11:58:19","slug":"sfb1328","status":"publish","type":"page","link":"https:\/\/freichel-lab.org\/?page_id=3531","title":{"rendered":"SFB1328"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3531\" class=\"elementor elementor-3531\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5dc2aa4 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"5dc2aa4\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3fc9a5f exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-sp-wp-tabs-shortcode-ew\" data-id=\"3fc9a5f\" data-element_type=\"widget\" data-widget_type=\"sp-wp-tabs-shortcode-ew.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style id=\"sp_tab_dynamic_style3530\">#sp-tabpro-wrapper_3530.sp-tab__lay-default .sp-tab__tab-content {width: 100%;}#sp-tabpro-wrapper_3530 .animated {-webkit-animation-duration: 500ms;animation-duration: 500ms;}#sp-wp-tabs-wrapper_3530 .sp-tab__nav {justify-content: start;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default.sp-tab__horizontal-bottom {display: flex;flex-direction: column-reverse;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default.sp-tab__horizontal-bottom > ul {border-top: 1px solid #cccccc;border-bottom: 0;margin-top: 0;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default.sp-tab__horizontal-bottom > ul > li .sp-tab__nav-link.sp-tab__active {border-color: transparent #cccccc#cccccc;margin-top: -1px;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default.sp-tab__horizontal-bottom > ul > li .sp-tab__nav-link,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default.sp-tab__horizontal-bottom > ul > li a,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default.sp-tab__horizontal-bottom > ul > .sp-tab__nav-item {border-top: 0;border-top-left-radius: 0;border-top-right-radius: 0;border-bottom-left-radius: 2px;border-bottom-right-radius: 2px;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default.sp-tab__horizontal-bottom > ul {border-bottom: none;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default.sp-tab__horizontal-bottom .sp-tab__tab-content .sp-tab__tab-pane {border-top: 1px solid #cccccc;border-bottom: 0;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default .sp-tab__tab-content .sp-tab-content > ul,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default .sp-tab__tab-content .sp-tab-content > ol {border-bottom: none;}#sp-wp-tabs-wrapper_3530 > .sp-tab__nav-tabs .sp-tab__nav-link.sp-tab__active .sp-tab__tab_title,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default .sp-tab__nav-link > .sp-tab__card-header {color: #ffffff;}#sp-wp-tabs-wrapper_3530 > .sp-tab__nav-tabs > .sp-tab__nav-item.show .sp-tab__nav-link,#sp-wp-tabs-wrapper_3530 > .sp-tab__nav-tabs > .sp-tab__nav-item .sp-tab__nav-link.sp-tab__active,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default .sp-tab__nav-link > .sp-tab__card-header {background-color: #0844b0;}#sp-wp-tabs-wrapper_3530 .sp-tab__nav-tabs .sp-tab__nav-item.show .sp-tab__nav-link,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default ul li .sp-tab__nav-link.sp-tab__active {border-color: #cccccc#cccccc transparent;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul > li > .sp-tab__nav-link,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul > li > a {cursor: pointer;border-color: #cccccc;padding-top: 15px;padding-right: 15px;padding-bottom: 15px;padding-left: 15px;}#sp-wp-tabs-wrapper_3530 > .sp-tab__nav-tabs .sp-tab__nav-link {border: 1px solid #cccccc;height: 100%;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul > li .sp-tab__nav-link,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul > li a,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul > .sp-tab__nav-item {border-top-left-radius: 2px;border-top-right-radius: 2px;}#sp-wp-tabs-wrapper_3530 .sp-tab__nav-tabs .sp-tab__nav-item {margin-bottom: -1px; }#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul .sp-tab__nav-item,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default .sp-tab__nav-link.collapsed > .sp-tab__card-header {background-color: #eee;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul .sp-tab__nav-item {margin-right: 10px;margin-top: 5px;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul .sp-tab__nav-item .sp-tab__nav-link:hover .sp-tab__tab_title,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul .sp-tab__nav-item a:hover .sp-tab__tab_title,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default .sp-tab__nav-link.collapsed .sp-tab__card-header:hover {color: #444;transition: .3s;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul .sp-tab__nav-item:hover,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default .sp-tab__nav-link.collapsed > .sp-tab__card-header:hover {background-color: #fff;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul .sp-tab__nav-item:last-child {margin-right: 0;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > .sp-tab__tab-content .sp-tab__tab-pane {border: 1px solid #cccccc;padding-top: 20px;padding-right: 20px;padding-bottom: 20px;padding-left: 20px;border-top: 0px;background-color: #ffffff;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul {border-bottom: 1px solid #cccccc;}@media(max-width:480px) {#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul li.sp-tab__nav-item {width: 100%;margin-right: 0px;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul li.sp-tab__nav-item:last-child {margin-bottom: -1px;}}#poststuff h2.sp-tab__section_title_3530, h2.sp-tab__section_title_3530 ,.editor-styles-wrapper .wp-block h2.sp-tab__section_title_3530{margin-bottom: 30px !important;font-weight: 600;font-style: normal;font-size: 28px;line-height: 28px;letter-spacing: 0px;padding: 0;color: #444444;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > ul .sp-tab__nav-item .sp-tab__tab_title,#sp-wp-tabs-wrapper_3530.sp-tab__lay-default span > .sp-tab__card-header {font-weight: 600;font-style: normal;font-size: 16px;line-height: 22px;letter-spacing: 0px;color: #444;margin: 0px;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > .sp-tab__tab-content .sp-tab__tab-pane {font-weight: 400;font-style: normal;font-size: 16px;line-height: 24px;letter-spacing: 0px;color: #444;}#sp-wp-tabs-wrapper_3530.sp-tab__lay-default > .sp-tab__tab-content .sp-tab__tab-pane ul li a, #sp-wp-tabs-wrapper_3530.sp-tab__lay-default .sp-tab__tab-content .sp-tab__tab-pane ol li a {color: #444;}<\/style>\t<h2 class=\"sp-tab__section_title_3530\"> SFB 1328<\/h2>\n\t\t\t<div id=\"sp-wp-tabs-wrapper_3530\" class=\"sp-tab__lay-default\" data-preloader=\"1\" data-activemode=\"tabs-activator-event-click\">\n\t\t\t<div class=\"sp-tab__preloader\">\n\t\t<div class=\"sp-tab__spinner\">\n\t\t\t<div class=\"rect1\"><\/div>\n\t\t\t<div class=\"rect2\"><\/div>\n\t\t\t<div class=\"rect3\"><\/div>\n\t\t\t<div class=\"rect4\"><\/div>\n\t\t\t<div class=\"rect5\"><\/div>\n\t\t<\/div>\n\t<\/div>\n\t<ul class=\"sp-tab__nav sp-tab__nav-tabs\" id=\"sp-tab__ul\" role=\"tablist\">\n\t\t\t\t<li class=\"sp-tab__nav-item\" role=\"presentation\">\n\t\t\t\t<span class=\"sp-tab__nav-link sp-tab__active\" data-sptoggle=\"tab\" for=\"#tab-35301\" role=\"tab\" aria-controls=tab-35301 aria-selected=true tabindex=0>\n\t\t\t\t\t<span class=\"tab_title_area\"><H4 class=\"sp-tab__tab_title\">A21<\/H4><\/span>\n\t\t\t\t<\/span>\n\t\t\t<\/li>\n\t\t\t<\/ul>\n<div class=\"sp-tab__tab-content\">\n\t\t\t\t<div id=\"tab-35301\" class=\"sp-tab__tab-pane sp-tab__show sp-tab__active\" role=\"tabpanel\">\n\t\t\t\t\t<div class=\"sp-tab-content animated fadeIn\"><h3 class=\"facelift\"><span style=\"color: #000000\">Adenine nucleotide signaling in Ca2+-dependent mast cell activation: role of endolysosomal and plasmalemmal channels.<\/span><\/h3>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000\">Mast cells are immune cells that essentially contribute to various inflammatory processes. Ca2+ entry and cytosolic Ca2+ rise is essential for inflammatory mediator release from mast cells. Adenine nucleotides (AN) such as adenosine, ATP or NAADP regulate mast cell Ca2+ homeostasis and function via endolysosomal two-pore channels (TPCs) and plasmalemmal channels. We will apply (endolysosomal) patch-clamp electrophysiology, imaging techniques, cell biological assays and mouse models to investigate the role of Orai and TPC channels and novel interaction partners of these for mast cell-mediated inflammation.<\/span><\/p>\n<p><span style=\"color: #000000\"><strong><span class=\"name\">Subproject of: <\/span><\/strong><\/span><span class=\"value\"><span style=\"color: #000000\"><a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/projekt\/335447717\">SFB 1328:\u00a0 Adenine Nucleotides in Immunity and Inflammation<\/a><\/span><br \/>\n<span style=\"color: #000000\"><strong><span class=\"name\">Project Heads: <\/span><\/strong><a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/person\/1773715\">Professor Dr. Marc Freichel<\/a>;\u00a0<a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/person\/233867230\">Professor Dr. Christian Michael Grimm<\/a><\/span><br \/>\n<\/span><\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>SFB 1328 A21 Adenine nucleotide signaling in Ca2+-dependent mast cell activation: role of endolysosomal and plasmalemmal channels Mast cells are immune cells that essentially contribute to various inflammatory processes. Ca2+ entry and cytosolic Ca2+ rise is essential for inflammatory mediator release from mast cells. Adenine nucleotides (AN) such as adenosine, ATP or NAADP regulate mast cell Ca2+ homeostasis and function via endolysosomal two-pore channels (TPCs) and plasmalemmal channels. We will apply (endolysosomal) patch-clamp electrophysiology, imaging techniques, cell biological assays and mouse models to investigate the role of Orai and TPC channels and novel interaction partners of these for mast cell-mediated inflammation. Subproject of: SFB 1328:\u00a0 Adenine Nucleotides in Immunity and Inflammation Project Heads: Professor Dr. Marc Freichel;\u00a0Professor Dr. Christian Michael Grimm<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-pagefull.php","meta":{"footnotes":""},"class_list":["post-3531","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages\/3531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3531"}],"version-history":[{"count":4,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages\/3531\/revisions"}],"predecessor-version":[{"id":3536,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages\/3531\/revisions\/3536"}],"wp:attachment":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}