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In addition, Ca<sup>2+<\/sup> channels and signaling pathways in macrophages contributing to cardiac remodeling through cardiocrine signaling will be identified.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>DZHK DZHK Targeting Ca2+-dependent arrhythmias and remodeling via inhibition of TRPC and endo-lysosomal channels We will develop therapeutic strategies to target TRPC, ORAI and endo-lysosomal channels with small molecules and by base and prime editing approaches. In addition, Ca2+ channels and signaling pathways in macrophages contributing to cardiac remodeling through cardiocrine signaling will be identified. &nbsp; &nbsp;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-pagefull.php","meta":{"footnotes":""},"class_list":["post-4228","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages\/4228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4228"}],"version-history":[{"count":7,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages\/4228\/revisions"}],"predecessor-version":[{"id":4242,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages\/4228\/revisions\/4242"}],"wp:attachment":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}