{"id":563,"date":"2024-07-07T16:58:22","date_gmt":"2024-07-07T16:58:22","guid":{"rendered":"https:\/\/freichel-lab.org\/?page_id=563"},"modified":"2024-11-05T14:00:42","modified_gmt":"2024-11-05T14:00:42","slug":"tr152p21","status":"publish","type":"page","link":"https:\/\/freichel-lab.org\/?page_id=563","title":{"rendered":"TR152P21"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"563\" class=\"elementor elementor-563\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f2bf43 e-flex e-con-boxed wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no e-con e-parent\" data-id=\"6f2bf43\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fdb364b exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-sp-wp-tabs-shortcode-ew\" data-id=\"fdb364b\" data-element_type=\"widget\" data-widget_type=\"sp-wp-tabs-shortcode-ew.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<style id=\"sp_tab_dynamic_style3481\">#sp-tabpro-wrapper_3481.sp-tab__lay-default .sp-tab__tab-content {width: 100%;}#sp-tabpro-wrapper_3481 .animated {-webkit-animation-duration: 500ms;animation-duration: 500ms;}#sp-wp-tabs-wrapper_3481 .sp-tab__nav {justify-content: start;}#sp-wp-tabs-wrapper_3481.sp-tab__lay-default.sp-tab__horizontal-bottom {display: flex;flex-direction: column-reverse;}#sp-wp-tabs-wrapper_3481.sp-tab__lay-default.sp-tab__horizontal-bottom > ul {border-top: 1px solid #cccccc;border-bottom: 0;margin-top: 0;}#sp-wp-tabs-wrapper_3481.sp-tab__lay-default.sp-tab__horizontal-bottom > ul > li .sp-tab__nav-link.sp-tab__active {border-color: transparent #cccccc#cccccc;margin-top: -1px;}#sp-wp-tabs-wrapper_3481.sp-tab__lay-default.sp-tab__horizontal-bottom > ul > li .sp-tab__nav-link,#sp-wp-tabs-wrapper_3481.sp-tab__lay-default.sp-tab__horizontal-bottom > ul > li a,#sp-wp-tabs-wrapper_3481.sp-tab__lay-default.sp-tab__horizontal-bottom > ul > .sp-tab__nav-item {border-top: 0;border-top-left-radius: 0;border-top-right-radius: 0;border-bottom-left-radius: 2px;border-bottom-right-radius: 2px;}#sp-wp-tabs-wrapper_3481.sp-tab__lay-default.sp-tab__horizontal-bottom > ul {border-bottom: none;}#sp-wp-tabs-wrapper_3481.sp-tab__lay-default.sp-tab__horizontal-bottom .sp-tab__tab-content .sp-tab__tab-pane {border-top: 1px solid #cccccc;border-bottom: 0;}#sp-wp-tabs-wrapper_3481.sp-tab__lay-default .sp-tab__tab-content .sp-tab-content > ul,#sp-wp-tabs-wrapper_3481.sp-tab__lay-default .sp-tab__tab-content .sp-tab-content > ol {border-bottom: none;}#sp-wp-tabs-wrapper_3481 > .sp-tab__nav-tabs .sp-tab__nav-link.sp-tab__active .sp-tab__tab_title,#sp-wp-tabs-wrapper_3481.sp-tab__lay-default .sp-tab__nav-link > .sp-tab__card-header {color: #ffffff;}#sp-wp-tabs-wrapper_3481 > .sp-tab__nav-tabs > .sp-tab__nav-item.show .sp-tab__nav-link,#sp-wp-tabs-wrapper_3481 > .sp-tab__nav-tabs > .sp-tab__nav-item .sp-tab__nav-link.sp-tab__active,#sp-wp-tabs-wrapper_3481.sp-tab__lay-default .sp-tab__nav-link > .sp-tab__card-header {background-color: #0844b0;}#sp-wp-tabs-wrapper_3481 .sp-tab__nav-tabs .sp-tab__nav-item.show .sp-tab__nav-link,#sp-wp-tabs-wrapper_3481.sp-tab__lay-default ul li .sp-tab__nav-link.sp-tab__active {border-color: #cccccc#cccccc transparent;}#sp-wp-tabs-wrapper_3481.sp-tab__lay-default > ul > li > .sp-tab__nav-link,#sp-wp-tabs-wrapper_3481.sp-tab__lay-default > ul > li > a {cursor: pointer;border-color: #cccccc;padding-top: 15px;padding-right: 15px;padding-bottom: 15px;padding-left: 15px;}#sp-wp-tabs-wrapper_3481 > .sp-tab__nav-tabs .sp-tab__nav-link {border: 1px solid #cccccc;height: 100%;}#sp-wp-tabs-wrapper_3481.sp-tab__lay-default > ul > li .sp-tab__nav-link,#sp-wp-tabs-wrapper_3481.sp-tab__lay-default > ul > li a,#sp-wp-tabs-wrapper_3481.sp-tab__lay-default > ul > .sp-tab__nav-item {border-top-left-radius: 2px;border-top-right-radius: 2px;}#sp-wp-tabs-wrapper_3481 .sp-tab__nav-tabs .sp-tab__nav-item {margin-bottom: -1px; 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However, the Ca2+-source(s) and their specific molecular link(s) to OCaRs are not yet resolved. In our project we will resolve the molecular environment of OCaRs using affinity, proximity and organellar proteomics in cardiomyocytes, pancreatic acinar cells and platelets. This will provide insight into cell-type specificity and mechanisms of OCaR controlled Ca2+ signalling, the physiological impact of which will be functionally investigated at cellular as well as at systemic level.<\/span><\/p>\n<p><span style=\"color: #000000\"><span class=\"name\"><strong>Subproject of: <\/strong><\/span><span class=\"value\"><a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/projekt\/239283807\">TRR 152:\u00a0 TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules<\/a><\/span><\/span><br \/>\n<span style=\"color: #000000\"><strong><span class=\"name\">Project Heads: <\/span><\/strong><span class=\"value\"><a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/person\/1773715\">Professor Dr. Marc Freichel<\/a>;\u00a0<a class=\"intern\" style=\"color: #000000\" href=\"https:\/\/gepris.dfg.de\/gepris\/person\/1668557\">Dr. Uwe Schulte<\/a>, since 7\/2022<\/span><\/span><\/p>\n<p><span style=\"color: #000000\"><strong>Website:<\/strong> <a style=\"color: #000000\" href=\"https:\/\/www.sfb-trr152.med.uni-muenchen.de\/crc-projects\/p21\/index.html\">https:\/\/www.sfb-trr152.med.uni-muenchen.de\/crc-projects\/p21\/index.html<\/a><\/span><\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>TR 152 P21 Project Description Funktionelle und molekulare Spezifit\u00e4t der OCaR-Kontrolle der intrazellul\u00e4ren Ca2+-Freisetzung OCaR1 and OCaR2, two intracellularly located membrane proteins, have been established as important controllers of NAADP-mediated Ca2+ signaling. However, the Ca2+-source(s) and their specific molecular link(s) to OCaRs are not yet resolved. In our project we will resolve the molecular environment of OCaRs using affinity, proximity and organellar proteomics in cardiomyocytes, pancreatic acinar cells and platelets. This will provide insight into cell-type specificity and mechanisms of OCaR controlled Ca2+ signalling, the physiological impact of which will be functionally investigated at cellular as well as at systemic level. Subproject of: TRR 152:\u00a0 TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules Project Heads: Professor Dr. Marc Freichel;\u00a0Dr. Uwe Schulte, since 7\/2022 Website: https:\/\/www.sfb-trr152.med.uni-muenchen.de\/crc-projects\/p21\/index.html<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-pagefull.php","meta":{"footnotes":""},"class_list":["post-563","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages\/563","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=563"}],"version-history":[{"count":22,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages\/563\/revisions"}],"predecessor-version":[{"id":3492,"href":"https:\/\/freichel-lab.org\/index.php?rest_route=\/wp\/v2\/pages\/563\/revisions\/3492"}],"wp:attachment":[{"href":"https:\/\/freichel-lab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=563"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}