We identified OCaR2 as a regulator of lysosomal two-pore channels, and its deletion resulted in Ca2+ oscillations in cardiomyocytes causing fatal catecholaminergic arrhythmias. We combine Ca2+ imaging, ECG telemetry, transcriptome and metabolome approaches with computational methods to elucidate pathways and patterns of gene regulation. By comparative analysis of circuits in arrhythmogenic cardiomyopathy models, we aim to determine common molecular circuits in the pathogenesis of catecholamine driven ventricular arrhythmias.
Subproject of: SFB 1550: Molecular Circuits of Heart Disease
Project Heads: Professor Dr. Marc Freichel; Rebecca Levinson, Ph.D.
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 464424253
Website: https://www.crc1550.com/project-b09
It is the central aim of the Integrated Research Training Group (IRTG) to promote young promising Cardioscientists. An ambitious study program dedicated to state of the art experimental approaches combining CRC 1550-specific training, mentoring and supervision will provide PhD and MD research students and post graduate young academics with the knowledge required for successful and efficient analysis of potential molecular circuits of heart disease. A completion of the program will not only increase competitiveness of our young academics in science and on the labor market but will also enhance the advancement of cardiovascular research by strengthening the leadership of future scientists’ generations in Cardioscience.
Subproject of: SFB 1550: Molecular Circuits of Heart Disease
Project Head: Professor Dr. Marc Freichel
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 464424253
Website: https://www.crc1550.com/project-s01